Weight-Loss drugs show potential in treating addiction and dementia

Written by Henrik Rothen

Aug.21 - 2023 10:16 AM CET

Foto: Shutterstock.com
Foto: Shutterstock.com
Weight-Loss drugs show potential in treating addiction and dementia

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Drugs like Ozempic, which have gained popularity as weight-loss solutions and treatments for type 2 diabetes, are now being researched for their potential benefits in treating conditions such as alcohol misuse and dementia. Ozempic and Wegovy, both containing the drug semaglutide, have been recognized for their ability to help individuals shed over 10% of their body weight. This has led researchers to explore their potential in other health areas.

Dr. Christian Hendershot from the University of North Carolina emphasized the effectiveness of these drugs for various health outcomes. He stated, "In some ways there is a sense that some of this might be too good to be true. But I think any potential benefits should be investigated."

The significant weight loss associated with these drugs has sparked interest in their potential impact on conditions linked to excessive weight, such as dementia, fatty liver, and various cancers. Dr. Harshal Deshmukh, a consultant endocrinologist at the University of Hull, highlighted the ongoing clinical trials investigating semaglutide's effects on these health conditions.

Novo Nordisk, the producer of Wegovy, recently announced that the drug could reduce major cardiovascular events' risk by 20% in overweight individuals or those with obesity. However, it remains uncertain whether these results are solely due to weight loss or if the drug has direct effects on the heart and blood vessels.

Another area of interest is polycystic ovary syndrome (PCOS), a condition affecting 8-13% of women of reproductive age. Dr. Deshmukh is leading a trial to study semaglutide's effects on weight, androgen reduction, and quality of life in women with PCOS.

Furthermore, drugs like semaglutide are being explored for their potential benefits in addiction treatment. Initial findings suggest that these drugs could affect drug-seeking behavior and consumption, especially concerning alcohol.

Even dementia researchers are turning to semaglutide, following studies indicating a reduced incidence of such conditions in individuals taking the drug for type 2 diabetes.

While these drugs show promise in various health areas, researchers emphasize the need for rigorous research. Concerns include the drugs' safety in non-overweight individuals, potential side effects, and issues of accessibility due to shortages and costs.

Dr. Kyle Simmons of Oklahoma State University remains optimistic, stating, "These drugs are already changing the world, we just don’t know whether they will change how we treat addiction."

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